Vincristine Sulfate

Character
Vincristine sulfate for injection: white or whitelike loose block or amorphous solid; There is moisture; Turns yellow easily when exposed to light or heat.
Indications
1. Acute leukemia, especially acute childhood leukemia, has a remarkable effect on acute lymphoblastic leukemia.
2. Malignant lymphoma.
3. Germ cell tumors.
4. Small cell lung cancer, Ewing's sarcoma, nephroblastoma, neuroblastoma.
5. Breast cancer, chronic lymphocytic leukemia, gastrointestinal cancer, melanoma, multiple myeloma, etc.
Specifications
Vincristine sulfate for injection: 1mg; 2 mg; 5 mg.

Different dosage forms and specifications of this product may vary, please read the specific drug instructions or follow the doctor's advice.
Vincristine sulfate for injection:
1. Adult dose of 1-2mg (or 1.4mg/m2) maximum dose not more than 2mg, aged over 65 years old, maximum dose of 1mg each time.
2, children 75μg/kg or 2.0mg/m2, once a week intravenously or rushed.
3. Combined chemotherapy is used continuously for a cycle of 2 weeks.

1. Dose-limiting toxicity is nervous system toxicity, mainly causing peripheral neurological symptoms, such as finger and neurotoxicity, and related to cumulative dose. Numbness of toes, slow or disappearance of tendon reflex, peripheral neuritis. Abdominal pain, constipation, paralytic ileus occasionally see. Motor, sensory and cerebral nerves can also be damaged, with corresponding symptoms. Neurotoxicity usually occurs in people over 40 years old, children are better tolerated than adults, and patients with malignant lymphoma are more prone to neurotoxicity than patients with other tumors.
2. Bone marrow suppression and digestive tract reaction were mild.
3. local tissue stimulation, liquid medicine can not leak, otherwise it can cause local necrosis.
4. visible hair loss, occasional changes in blood pressure.

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